Genetic variation in human apolipoprotein E
نویسندگان
چکیده
منابع مشابه
AN INVESTIGATION OF HUMAN APOLIPOPROTEIN E POLYMORPIDSMS IN MULTIPLE SCLEROSIS PATIENTS OF IRAN
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...
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The conformations of apolipoproteins on the surfaces of lipoprotein particles affect their physiologic functions. The conformations of apoE on plasma lipoproteins were examined using a panel of eight anti-apoE monoclonal antibodies (MAbs). The antibodies, which reacted with the major isoforms of apoE (E2, E3, and E4), defined at least five epitopes on apoE. Proteolytic fragments and synthetic p...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1982
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)38055-x